Traffic Pollution Changes Genes in the Womb and Increases Asthma Risk
New research suggests that pollution from traffic can ‘reprogram’ genes in the womb, increasing the risk for asthma. The study is the first to link pollution to genetic changes, although researchers say that more studies are needed to confirm the findings.
The study, published in PLoS ONE Journal, looked at ACSL3, a gene expressed in the lung, and its association with asthma in children at or around age 5. The mothers’ exposure (while pregnant) to polycyclic aromatic hydrocarbons (PAHs) was recorded, and the umbilical cord blood from their children was examined for the modified gene.
“Our data support the concept that environmental exposures can interact with genes during key developmental periods to trigger disease onset later in life, and that tissues are being reprogrammed to become abnormal later.” - Dr Shuk-mei Ho, study leader and director of the Center for Environmental Genetics at the University of Cincinnati.


